True or False: Angina pectoris without ischemic ECG changes can still indicate CAD.

The statement is true because angina pectoris can occur without any ischemic changes noted on an electrocardiogram (ECG), but it may still signal the presence of coronary artery disease (CAD). Angina is characterized by chest pain or discomfort that arises due to the heart muscle not getting enough blood and oxygen, typically due to narrowed arteries.

In some cases, individuals may experience angina symptoms despite having a normal ECG during the episode or at rest, which means that there are no visible signs of ischemia on the ECG at those times. This does not negate the possibility of underlying CAD. The absence of ischemic changes on the ECG does not rule out the potential for atherosclerotic plaques or other abnormalities in the coronary arteries that could be causing the angina.

Overall, the presence of angina pectoris, regardless of ECG findings, warrants further investigation for CAD, as it could represent a significant underlying cardiac risk even in the absence of immediate ischemic evidence.