True or False: ST-segment depression can localize ischemia to a specific area of myocardium.

The statement that ST-segment depression can localize ischemia to a specific area of myocardium is false. While ST-segment depression is a recognized indicator of myocardial ischemia, it does not provide sufficient specificity to pinpoint the exact location of the affected myocardial tissue.

Electrocardiographic changes such as ST-segment depression indicate an imbalance between supply and demand of oxygen in the myocardium, which can result from ischemia. However, these changes can occur due to various factors that might not relate to a specific coronary artery zone or myocardial region, including global ischemia, the presence of systemic conditions, or even physiological responses to stress.

As such, while ST-segment depression can signal the occurrence of ischemia, it lacks the capacity to definitively localize the ischemic area, making it important to use additional diagnostic modalities such as imaging or further cardiac assessment for precise localization and evaluation of myocardial ischemia.